Buy Bronchogen Peptide Poland
Bronchogen is a peptide bioregulator designed to support respiratory health by promoting lung tissue repair, reducing inflammation, enhancing breathing function, and improving overall respiratory system resilience.
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What is Bronchogen?
Bronchogen is a synthetic tetrapeptide classified as a Cytogen, a peptide bioregulator. It mimics natural peptides in the bronchial mucous membrane and supports cellular processes that restore and maintain respiratory function. By influencing gene expression and protein synthesis in the lungs, bronchi, and alveoli, Bronchogen promotes cell repair and regeneration. Composed of alanine, glutamic acid, aspartic acid, and leucine, it acts at a foundational level to restore normal lung function and enhance tissue resilience to environmental stressors and aging.
Bronchogen Mechanism Of Action
Bronchogen reduces inflammation in the bronchial airways by inhibiting pro-inflammatory cytokines such as IL-6 and TNF-alpha, which contribute to airway hyperresponsiveness and tissue damage. It also promotes bronchodilation by activating beta-2 adrenergic receptors, relaxing airway smooth muscle, and improving airflow.
Bronchogen stimulates ciliary activity to enhance mucociliary clearance and support the removal of mucus and debris. Its antioxidant properties neutralize reactive oxygen species, protecting lung tissue from oxidative stress. These combined actions help alleviate symptoms, improve lung function, and address underlying causes of respiratory diseases, offering a comprehensive approach to respiratory health.
Structure of Bronchogen
Sequence: H-Glu-Asp-Leu-Ala-OH
Molecular Formula: C18H30N4O9
Molecular Weight: 446.5 g/mol
PubChem CID: 471572
What Are The Research Benefits of Bronchogen?
Restoration and Regeneration of Bronchial Epithelium: In experimental models of chronic obstructive pulmonary disease (COPD), the tetrapeptide Bronchogen significantly restores the bronchial epithelium. In rats with NO2-induced lung damage, a one-month Bronchogen course reverses key pathological changes. It eliminates bronchial remodelling, including goblet cell hyperplasia and squamous metaplasia, and restores ciliated cells [1].
Bronchogen also reduces neutrophilic inflammation by normalising pro-inflammatory cytokines in the bronchoalveolar space. These structural and anti-inflammatory effects are supported by functional improvements, including increased production of secretory IgA, a marker of local immunity, and surfactant protein B, which is essential for alveolar stability [2].
Reduction of Pulmonary Inflammation: Recent Poland research using a rat model of COPD demonstrates the significant anti-inflammatory potential of Bronchogen. In subjects exposed to intermittent nitrogen dioxide for 60 days, Bronchogen treatment markedly reduced neutrophilic inflammation in the lungs. Analysis of bronchoalveolar lavage fluid (BALF) showed normalisation of cellular composition and pro-inflammatory cytokine and enzyme profiles.
In addition to reducing inflammation, Bronchogen restored functional lung immunity, as shown by increased levels of secretory immunoglobulin A (sIgA) and surfactant protein B, which are critical for local immune defence and alveolar stability. These findings indicate that Bronchogen effectively modulates the inflammatory response and supports the restoration of essential pulmonary defence mechanisms [2].
Support of Local Immune Defense: Bronchogen Poland enhances local immune defences by normalising the functional activity of the bronchial epithelium. In experimental COPD models, its administration significantly increased production of secretory immunoglobulin A (sIgA), a key marker for local immunity that protects mucosal surfaces from pathogens and inflammatory triggers [1].
DNA Stabilization and Gene Regulation: Bronchogen stabilizes DNA by increasing its melting temperature, reflecting strong binding to nitrogen bases. Poland Studies show it penetrates cell nuclei and interacts specifically with CTG-containing sequences, distinguishing among nucleotide patterns. These site-specific interactions allow Bronchogen to influence epigenetic mechanisms and potentially regulate gene expression and protein synthesis [3].
By affecting DNA methylation and gene promoters, it supports genomic stability [4]. This regulatory capacity indicates Bronchogen plays a key role in cellular function and genetic integrity during replication and transcription. Its ability to interact with DNA and regulate gene expression suggests potential as a therapeutic agent for conditions involving genetic instability, including aging, cancer, and chronic diseases [5].
Support for Surfactant Production and Lung Mechanics: Bronchogen supports lung function by promoting surfactant production. Poland Studies in lung injury models show that it increases surfactant proteins A and B, which lowers alveolar surface tension, improves lung compliance, and enhances the transfer of oxygen and carbon dioxide [6].
Buy Bronchogen Poland for laboratory research online today!
Bronchogen Peptide Quality Assured
Buy Bronchogen peptide Poland with 99% purity from Direct Peptides, designed specifically for advanced scientific research. Each vial undergoes rigorous third-party testing to ensure exceptional quality and reliability, giving researchers complete confidence in their experimental results. Count on our peptides for safety, precision, and consistent support in advancing your respiratory research projects.
Summary of Research Applications
- Improves respiratory function.
- Promotes lung tissue repair.
- Helps lower inflammation.
- Reduces oxidative stress.
- Supports the immune system.
Buy Bronchogen Peptide Vial
Buy Bronchogen peptide vial, available in a 20 mg vial or as a complete kit that includes bacteriostatic and syringes.
Frequently Asked Questions (FAQs) about Bronchogen Peptide
Is Bronchogen legal to buy?
Bronchogen Poland is described as an investigational therapeutic, which means it is currently under research and development. Its legal status depends on the regulatory framework of the country in question. Typically, investigational therapies are not approved for general use and are only available within the context of clinical trials or research studies authorized by regulatory bodies like the FDA (in the United States) or EMA (in Europe).
If you are considering its use or research, it’s essential to consult the relevant regulatory guidelines and ensure compliance with local laws and institutional protocols.
Does Bronchogen have a direct effect on bronchodilation?
While not its primary mechanism, Bronchogen indirectly supports improved airflow. By reducing mucosal inflammation and oedema, and promoting the health of airway smooth muscle, it contributes to a more favourable environment for normal bronchodilation, rather than acting as a direct-acting bronchodilator like a beta-2 agonist.
Are there any known contraindications or significant side effects?
In current research settings, Bronchogen has demonstrated a high safety profile with minimal reported side effects. However, it is contraindicated for individuals with a known hypersensitivity to any of its components. As with any investigational compound, researchers should monitor subjects closely for any adverse reactions.
How does Bronchogen differ from conventional respiratory treatments like corticosteroids or bronchodilators?
Bronchogen differs by offering a potentially regenerative and regulatory approach rather than a purely symptomatic one. While corticosteroids manage inflammation and bronchodilators relieve airway constriction, Bronchogen aims to address the underlying cellular dysfunction and promote the restoration of healthy bronchial tissue.
Can Bronchogen be used in conjunction with other respiratory therapies?
The synergistic potential of Bronchogen with other therapies is an active area of investigation. Its unique mechanism of action suggests it could complement standard treatments by targeting different pathological pathways. Any combined use should be conducted under a strictly controlled research protocol.
Buy Bronchogen for research purposes today from Direct Peptides Poland online.
References For Further Reading
[1] Kuzubova NA, Lebedeva ES, Dvorakovskaya IV, Surkova EA, Platonova IS, Titova ON. Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology. Bulletin of Experimental Biology and Medicine, 2015 Sep, Volume 159 (Issue 5), Pages 685-8.
[2] Titova ON, Kuzubova NA, Lebedeva ES, Preobrazhenskaya TN, Surkova EA, Dvorakovskaya IV. [ANTIINFLAMMATORY AND REGENERATIVE EFFECT OF PEPTIDE THERAPY IN THE MODEL OF OBSTRUCTIVE LUNG PATHOLOGY]. Ross Fiziol Zh Im I M Sechenova. 2017 Feb, Volume 103 (Issue 2), Pages 201-8. Russian. PMID: 30199201.
[3] Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, Khachidze DG, Lomidze EM, Jokhadze TA, Lezhava TA. Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability. Bull Exp Biol Med. 2011 Jan, Volume 150 (Issue 3), Pages 375-7.
[4] L. I. Fedoreyeva, I. I. Kireev, V. Kh. Khavinson & B. F. Vanyushin. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Moscow). 19 November 2011, Volume 76, pages 1210–1219.
[5] Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021, Volume 26 (Issue 22), Page 7053.
[6] Han S, Mallampalli RK. The Role of Surfactant in Lung Disease and Host Defense against Pulmonary Infections. Annals of the American Thoracic Society. 2015 May, Volume 12 (Issue 5), Pages 765-74.
Why Choose Direct Peptides Poland?
Buy Bronchogen peptides with Direct Peptides Poland. Our high-purity 20mg vials are designed for precise dosing in advanced research, supporting lung tissue maintenance and inflammation studies. Trust us for reliable, high-grade formulations tailored to your scientific needs.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Poland Direct Peptides website: https://direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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The Role of the Bronchogen Peptide for Lung Tissue Research
This blog explores how Bronchogen supports lung tissue integrity by stabilizing epithelial cells and reducing inflammation in lab models. By comparing it to peptides like VIP and B7-33, the article highlights Bronchogen's potential for advancing respiratory research through improved airway regulation and tissue preservation.