Buy MGF Peptide Poland
Buy MGF peptide Poland (Mechano Growth Factor), it is known for its potential benefits in promoting muscle regeneration, enhancing recovery from injuries, and supporting the growth and repair of muscle tissues through its role in stimulating satellite cell activation and proliferation.
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MGF Nasal Spray
£26.24 – £47.48 This product has multiple variants. The options may be chosen on the product page -
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MGF 2mg Pre Mixed
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MGF
£17.54 – £26.52 This product has multiple variants. The options may be chosen on the product page
What Is MGF Peptide?
MGF, or Mechano Growth Factor, is a variant of the insulin-like growth factor-1 (IGF-1) gene, playing a key role in tissue growth, repair, and regeneration. IGF-1 research highlights its splicing and isoform production, with the IGF-1Ec isoform (MGF) showing strong potential in muscle repair and recovery.
The three IGF-1 isoforms differ in their amino acid sequence at the COOH terminal, and MGF levels notably increase after muscle injury. This peptide, made up of 24 amino acids, is mainly produced in response to mechanical stress or injury, triggering anabolic processes for tissue repair and strengthening.
MGF effectively stimulates satellite cell activation and proliferation, essential for muscle regeneration and growth. Synthetic variants like MGF-Ct24E have further enhanced muscle cell growth and protein synthesis. Factors like growth hormone levels and resistance training significantly boost MGF mRNA levels.
Beyond muscle repair, MGF has potential in neuroprotection, cardioprotection, and reducing muscle cell death. It may also aid recovery in neurological conditions. This versatile peptide continues to draw interest for its broad applications in promoting tissue repair and cellular health
MGF Peptide Mechanism Of Action
Mechano Growth Factor functions by activating satellite cells, which are specialised stem cells found in muscle tissue. When muscles experience mechanical stress or damage, such as during intense exercise, MGF is upregulated and released as part of the body’s repair mechanism.
This peptide binds to specific receptors on satellite cells, stimulating their activation and encouraging them to proliferate (increase). The newly activated satellite cells then combine with existing muscle fibres, contributing to growth, strength, and repair.
Furthermore, it increases the rate of protein synthesis within muscle cells, enabling faster muscle recovery and hypertrophy (muscle growth). By triggering these vital cellular processes, it supports both structural and functional improvements in muscle tissue. Its regenerative properties also make it a promising agent for treating muscle-wasting conditions or aiding recovery from injuries.
Structure of MGF Peptide
Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys
Molecular Formula: C124H204N42O41S1
Molecular Weight: 2971.99 g/mol
What Are The Research Benefits of MGF Peptide
Skeletal Muscle Regeneration: Peptide therapy research emphasises the crucial role of mechano-growth factor in muscle inflammation and repair processes. Following muscle injury, MGF levels rapidly increase and are primarily produced by macrophages. Overexpression of MGF in injured muscles has been shown to delay the resolution of pro-inflammatory macrophages and elevate inflammatory markers, likely due to a reduction in macrophage cell death. Although the overall impact on muscle regeneration appears limited, its key function lies in regulating inflammation during the repair process [1].
A study involving mice with induced muscle contusion revealed that exposure to MGF significantly reduced levels of inflammatory markers such as cytokines, chemokines, oxidative stress markers, and matrix metalloproteinases (MMPs). This indicates that MGF may help alleviate inflammation and fibrosis, ultimately supporting long-term muscle repair. Furthermore, it appears to attenuate fibrosis by reducing collagen types I and III in the extracellular matrix [2].
Activation of Muscle Stem Cells: Skeletal muscle repair relies heavily on satellite cells (stem cells) as damaged cells cannot regenerate on their own. Two IGF-1 gene variants are pivotal in the muscle injury response:
- MGF plays a critical role by activating satellite cells immediately following damage,
- IGF-IEa facilitates protein synthesis later in the repair process.
This activation process supports muscle formation and enhances the migration of mesenchymal stem cells and other stem cells to the injury site. Research conducted on muscle cell cultures highlights the distinct and complementary roles these two gene variants play in muscle regeneration.
Muscle Wasting: Cellular senescence reduces satellite cell activation in older individuals, contributing to sarcopenia and impaired muscle mass and repair. Aging is linked to lower MGF expression, a variant of IGF-1. Research shows the MGF-24aa-E peptide can enhance satellite cell activity and muscle repair in younger cells, but it is less effective in older adults. This peptide offers a potential strategy to fight age-related muscle loss without the cancer risks of IGF-1 [4].
Cartilage and Joint Health: Poland Studies show MGF, an isoform of IGF-1, is crucial for cartilage and joint health. It is highly expressed in chondrocytes, especially in damaged cartilage from trauma or osteoarthritis, and affects processes like cell growth, migration, differentiation, inflammation, and apoptosis. It also reacts to mechanical stimuli, helping maintain cartilage balance. While important for tissue repair and chondrocyte activity, its exact role in cartilage development and disease is still unclear [5].
Neuroprotective Effects: As a variant of IGF-1, the peptide shows potential neuroprotective benefits, including promoting neurogenesis and nerve regeneration, enhancing cognitive function and brain health, and offering neuroprotection in neurodegenerative diseases like Alzheimer’s and Parkinson’s. It may aid in cellular repair, reduce oxidative stress, and combat inflammation in the brain, supporting overall neuronal health and recovery [6].
Poland Research studies on mouse models examined how higher MGF levels affect brain cells. Researchers bred mice to overproduce MGF in the hippocampus, a region vital for neurogenesis. This led to increased levels of BrdU, a marker of cell growth. Mice were bred for controlled MGF production at 1, 3, and 12 months, with responses analyzed after 2 years. Results showed high concentrations of BrdU and improved neurogenesis [7].
Cardiovascular Support: Researchers have investigated the effects of delivering a synthetic peptide derived from the mechano-growth factor E-domain to the heart muscle after a myocardial infarction (heart attack) [8]. By utilising bioengineered polymeric microrods to deliver the peptide in mice, they observed significant improvements in cardiac function, reduced mortality rates, and delayed heart muscle decompensation. The treatment was found to inhibit pathological hypertrophy and adverse remodeling of the heart muscle, highlighting its potential as a therapeutic approach for improving heart function and recovery following an infarction [9].
Buy MGF Peptide Vial 2 mg Poland for laboratory research use from Direct Peptides online today!
The freeze-dried powder in the vial will need to be reconstituted with bacteriostatic water before use. Shop all peptide supplies here.
Buy MGF Peptide Pre-Mixed Pen
Buy MGF Peptide 2 mg pre-mixed pen, a ready-to-use device that simplifies administration with no manual mixing, ensuring convenience and reducing contamination risk.
The Pre-Mixed Cartridge and Kit includes a preloaded peptide cartridge, Bacteriostatic Water, pen, case, and needle tips. Single cartridges come with needle tips but not the full kit. Save 10% on sets of 3 cartridges.
Buy MGF Peptide Nasal Spray
Buy MGF peptide nasal spray, an alternative non-invasive delivery method for Mechano Growth Factor.
Available in 15 ml and 30 ml spray bottles, this form of the peptide offers convenience and ease of use, eliminating the need for needles or injections. Each bottle is pre-formulated to ensure accurate dosing and consistent results, making it a practical option for researchers.
Frequently Asked Questions (FAQs) about MGF Peptide
Is MGF peptide legal?
The legality varies by country. In many places, it is not approved for medical use or as a supplement due to limited clinical trials and lack of FDA approval for human consumption. Often, it is only available for research purposes. Always check and follow local laws before considering its use.
Is MGF peptide legal in sports?
Due to its performance-enhancing properties, the use in sports is regulated. It may fall under substances banned by the World Anti-Doping Agency (WADA), so athletes should be cautious and consult relevant guidelines.
How is MGF peptide administered?
It is typically administered through injections directly at the site of injury or into a targeted area. Its dosage and duration of therapy depend on the intended application and individual needs.
Are there any side effects of MGF peptide?
Potential side effects may include localized pain or irritation at the injection site. Since research is still ongoing, other long-term effects have yet to be fully understood. It is advisable to use MGF under medical supervision.
What is the difference between MGF and PEG MGF?
MGF (Mechano Growth Factor) and PEG-MGF (Pegylated Mechano Growth Factor) are related peptides but differ in their stability and duration of action. MGF is a naturally occurring peptide produced as a response to muscle damage, and it has a relatively short half-life, limiting its effectiveness in the body.
Pegylated Mechano Growth Factor (PEG-MGF), on the other hand, is a modified version of MGF where a polyethylene glycol (PEG) molecule is attached to enhance stability and extend its half-life. This modification allows PEG-MGF to remain active in the system for a longer period, potentially improving its efficacy in promoting muscle repair and growth.
Buy MGF Peptide Poland for research purposes from Direct Peptides.
Summary of Research Applications
- Improved muscle function.
- Muscle hypertrophy due to increased muscle cell size.
- Potential treatment for muscle wasting diseases such as Duchenne muscular dystrophy (DMD).
- Enhanced wound healing.
- Improved heart health.
- Neuroprotective.
- Potential protection against ischemic stroke.
Buy MGF Peptide for research into cartilage regeneration and muscle development.
MGF Peptide Quality Assured
Buy MGF peptide with 99% purity from Direct Peptides, specifically designed for scientific research. Every product undergoes rigorous testing to ensure exceptional quality and reliability, providing researchers with the confidence they need for accurate results. Trust our peptides for unmatched safety, precision, and consistent support in advancing your work.
References For Further Reading
[1] Keng-Ting Sun, Kwok-Kuen Cheung, Shannon W N Au, et al (2018) Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury – Frontiers in Physiology, 2018 Jul 26, Volume 9, Page 999.
[2] Xiaoguang Liu, Zhigang Zeng, Linlin Zhao, Peijie Chen, and Weihua Xiao (2019) Impaired Skeletal Muscle Regeneration Induced by Macrophage Depletion Could Be Partly Ameliorated by MGF Injection – Frontiers in Physiology, 2019 May 17, Volume 10, Page 601.
[3] Maria Hill, A Wernig, and G Goldspink (2003) Muscle satellite (stem) cell activation during local tissue injury and repair – Journal of Anatomy, 2003 Jul, Volume 203 (Issue 1), Pages 89–99.
[4] Prashanth Kumar Kandalla, Geoffrey Goldspink, Gillian Butler-Browne, and Vincent Mouly (2011) Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages – Mechanisms of Ageing and Development, Volume 132, Issue 4, April 2011, Pages 154-162.
[5] Yi Liu, Mengmeng Duan, Demao Zhang, and Jing Xie (2023) The role of mechano growth factor in chondrocytes and cartilage defects: a concise review – Acta Biochimica Biophysica Sinica (Shanghai), 2023 May 12, Volume 55 (Issue 5), Pages 701–712.
[6] Jason J Tang, Jewel L Podratz, Miranda Lange, Heidi J Scrable, et al (2017) Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain – Molecular Brain, 2017 Jul 7, Volume 10, Page 23.
[7] Jason J Tang, Jewel L Podratz, Miranda Lange, Heidi J Scrable, et al (2017) Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain – Molecular Brain, 2017 Jul 7, Volume 10 (Issue 1), Page 23.
[8] Evangelos Mavrommatis, Krystyna M Shioura, Tamara Los, and Paul H Goldspink (2013) The E-domain region of mechano-growth factor inhibits cellular apoptosis and preserves cardiac function during myocardial infarction – Molecular and Cellular Biochemistry, 2013 May 28, Volume 381 (Issue 1), Pages 69–83.
[9] Yongqiang Sha, Liping Chen, Chunming Xu, Beibei Zhang, et al (2023) The Roles of IGF-1 and MGF on Nerve Regeneration under Hypoxia- Ischemia, Inflammation, Oxidative Stress, and Physical Trauma – Current Protein & Peptide Science, 2023, Volume 24 (Issue 2), Pages 143-155.
Why Choose Direct Peptides Poland?
Buy MGF Peptide Poland today from Direct Peptides, your reliable source for high-quality peptides. We provide a range of options to suit your needs, including 2 mg peptide vials, 15ml and 30ml peptide nasal sprays, and 2 mg pre-mixed peptide pens. Our products are designed to support various research needs, giving researchers access to the exact formulations required for their projects.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Poland Direct Peptides website: https://poland.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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